In pre-Columbian times, the region of Azuero was populated by the indigenous Guaymies, now known as the Ngäbe, who were dedicated to fishing, hunting and agriculture, maize being their main agricultural product. These towns were almost eliminated by the bloody battles that occurred at the time by the Spanish conquest.
The Spanish invasion in the Region of Azuero began in 1515. The Spanish met the indigenous peoples led under the command of Caciques like Paris, Parita, Nata, Penonome, among others. Instead of resisting to the Spanish soldiers, they offered them gold ornaments and fled towards the mountains.